The sermon focuses on the theme of change and the challenges it presents. It emphasizes that while change is difficult, it is necessary for growth and improvement in various aspects of life, such as health, finances, relationships, and spirituality. The sermon uses the example of New Year's resolutions to illustrate how people often struggle with change, but it encourages listeners to prioritize their relationship with Jesus as the foundation for all other changes. The message is reinforced with the story of Jesus calling Simon and Andrew to follow Him, highlighting the importance of immediate action and commitment to change.